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Changes in proteins play important role in aging kidneys

Changes in proteins play important role in aging kidneys
Science
"Physiological changes in kidney function during aging are well documented, but little is known about the underlying molecular processes that drive this loss of function," explains first author Yuka Takemon, who was a research assistant at the Jackson Laboratory in Bar Harbor, Maine, US, when the study was carried out, and is now a PhD student at the Michael Smith Genome Sciences Centre, University of British Columbia, Canada. "Many previous studies of these physiological changes have looked at the transcription of genes into proteins by measuring messenger RNA (mRNA), but we wanted to see if we could gather more insights by combining this approach with studying protein levels in the kidney."

However, not all of the changes in proteins corresponded with changes in the mRNA, suggesting that some of the protein changes occur after the transcription of genes into RNA. This could mean that older kidneys become less efficient at building new proteins, or that proteins are broken down more quickly in older kidneys. If further studies confirm this, it could mean that therapies or interventions that promote protein building or slow protein breakdown may be beneficial for treating kidney diseases associated with aging.

Materials provided by eLife . Note: Content may be edited for style and length.

eLife. "Changes in proteins play important role in aging kidneys." ScienceDaily. ScienceDaily, 4 May 2021. .

eLife. "Changes in proteins play important role in aging kidneys." ScienceDaily. www.sciencedaily.com/releases/2021/05/210504112615.htm (accessed May 4, 2021).

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