Gene associated with autism linked to itch response, study finds

Gene associated with autism linked to itch response, study finds
A pilot study from North Carolina State University has found that a gene associated with autism spectrum disorder (ASD) and pain hypersensitivity may actually decrease itch response. Atopic dermatitis and pain hypersensitivity are both conditions associated with some types of ASD.


The gene in question, contactin associated protein 2 (CNTNAP2), is thought to be linked to a mutation associated with some forms of autism. This gene is found throughout the dorsal root ganglia (DRG), which are clusters of sensory cells located at the root of the spinal nerves. The DRG is the superhighway that transmits sensations of both pain and itch from the skin through the spinal cord to the brain.

"Since atopic dermatitis is often associated with ASD and CNTNAP2 is both linked to pain hypersensitivity in ASD and expressed in almost all DRG sensory neurons, we wondered whether CNTNAP2 might also contribute to itch behavior," says Santosh Mishra, assistant professor of neuroscience at NC State and author of the study.

Mishra compared itch response in mice with the CNTNAP2 gene to those without it. In the presence of both histamine and non-histamine based stimuli, the CNTNAP2 knock-out mice, or mice without the gene, had a reduced itch response compared to mice with the gene.

"If there is a link between ASD and atopic dermatitis, then mice without a normal CNTNAP2 gene would be expected to have an increased itch response just as they have increased sensitivity to pain," Mishra says. "There are several possible explanations for this finding, ranging from standard physiological differences between humans and animals to CNTNAP2 s potential role in releasing neuropeptides that could affect this response.

"But we also know that pain can suppress itch sensation and vice versa. Just as some humans with ASD have higher pain sensitivity, so do mice without CNTNAP2. That pain sensitivity may be inhibiting the itch sensation."

Mishra hopes that this pilot study may pave the way to further exploration of the role of CNTNAP2 in itch.

"The functional role of CNTNAP2 in the neural transmission of itch is unknown," Mishra says. "While this study sheds light on the possible linkage between ASD and itch, it s limited because it is primarily based on behavioral, not cellular or molecular, results. Future studies may be required to dissect the molecular underpinnings of CNTNAP2 and itch sensation."

The study appears in the Journal of Investigative Dermatology and was supported by the National Institutes of Health and NC State seed funding.

Materials provided by North Carolina State University . Original written by Tracey Peake. Note: Content may be edited for style and length.

North Carolina State University. "Gene associated with autism linked to itch response, study finds." ScienceDaily. ScienceDaily, 29 July 2021. .

North Carolina State University. "Gene associated with autism linked to itch response, study finds." ScienceDaily. (accessed July 29, 2021).



July 23, 2019 — A de novo gene mutation that encodes a brain protein in a child with autism has been placed into the brains of mice. These mice then showed severe alterations of specific behaviors that closely ...

Oct. 26, 2018 — Autism spectrum disorder (ASD) affects children s social and intellectual development. Conventional diagnostic methods for ASD rely on behavioral observation. Researchers have now identified a ...

Oct. 17, 2018 — In the largest genetic sequencing study of autism spectrum disorder (ASD) to date, researchers have identified 102 genes associated with ASD, and report significant progress toward teasing apart the ...

Sep. 15, 2016 — The sense of touch may play a more crucial role in autism spectrum disorder (ASD) than previously assumed. The main findings of the research show that individuals with ASD may have difficulties to ...
News Topics :
Stop scratching rubbing skin activates an anti itch pathway in the spinal cord, according to research in mice recently published in JNeurosci. advertisement It can be hard to resist the relief...
In addition to a skin rash, many eczema sufferers also experience chronic itching, but sometimes that itching can become torturous. Worse, antihistamines the standard treatment for itching and allergy...
Autism is considered a disorder of the brain. But a new study suggests that the peripheral nervous system, the nerves that control our sense of touch, pain and other sensations,...
The findings, from researchers at Imperial College London and University of South Carolina, add to mounting evidence that inflammation, and the accompanying release of the molecule histamine, affects a key...
Chronic skin itching drives more people to the dermatologist than any other condition. In fact, the latest science literature finds that 7 of U.S. adults, and between 10 and 20...