Memories create fingerprints that reveal how the brain is organized

Memories create  fingerprints  that reveal how the brain is organized
While the broad architecture and organization of the human brain is universal, new research shows how the differences between how people reimagine common scenarios can be observed in brain activity and quantified. These unique neurological signatures could ultimately be used to understand, study, and even improve treatment of disorders such as Alzheimer s disease.


The participant s verbal descriptions were mapped to a computational linguistic model that approximates the meaning of the words and creates numerical representation of the context of the description. They were also asked to rate aspects of the remembered experience, such as how strongly it was associated with sound, color, movement, and different emotions.

The study volunteers were then placed in a functional MRI (fMRI) and asked to reimagine the experience while researchers measured which areas of the brain were activated. Using the fMRI data and the subject s verbal descriptions and ratings, researchers were able to isolate brain activity patterns associated with that individual s experiences. For instance, if the participant imagined driving through a red light in the scenario, areas of the brain associated with recalling motion and color would be activated. Using this data, the researchers built a functional model of each participant s brain, essentially creating a unique signature of their neurological activity.

The researchers were able to identify several areas of the brain that served as hubs for processing information across brain networks that contribute to recalling information about people, objects, places, emotions, and sensations. The team was also able to observe how activation patterns within these networks differed on an individual level depending upon the details of each person s recollections and imagination.

"One of the goals of cognitive science is to understand how memories are represented and manipulated by the human brain," said Andrew Anderson, Ph.D., with the Del Monte Institute for Neuroscience and co-author of the study. "This study shows that fMRI can measure brain activity with sufficient signal to identify meaningful interpersonal differences in the neural representation of complex imagined events that reflect each individual s unique experience."

In addition to expanding our understanding of how the brain is networked, the authors point out that many of the key regions they identified tend to decline in function as we age and are vulnerable to the degeneration that occurs in disease like Alzheimer s. The findings could lead to new ways to diagnose and study disorders associated with irregular memory deficits, including dementia, schizophrenia, and depression, and perhaps even personalize treatments and predict which therapies will be more effective.

The study was funded with support from the National Center for Advancing Translational Sciences of the National Institutes of Health and the URMC Clinical the Translational Science Institute.

Materials provided by . Original written by Mark Michaud. Note: Content may be edited for style and length.

University of Rochester Medical Center. "Memories create fingerprints that reveal how the brain is organized." ScienceDaily. ScienceDaily, 20 November 2020. .

University of Rochester Medical Center. "Memories create fingerprints that reveal how the brain is organized." ScienceDaily. (accessed November 20, 2020).



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